atorvastatin

/əˌtɔːrvəˈstætɪn/ Mechanism of action Competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis. Reduced intracellular cholesterol upregulates hepatic LDL receptors, increasing LDL-C clearance from plasma. Also has pleiotropic effects: plaque stabilization, anti-inflammatory (lowers hs-CRP), improved endothelial function \\[1\\]. Standard dosing -/

International Phonetic Alphabet (IPA).

Generic name: atorvastatin

Brand names: Lipitor

Therapeutic class: HMG-CoA reductase inhibitor (statin)

Full drug cards with dosing, warnings, interactions, and practice questions are inside NAPLEX Prep.