warfarin

/ˈwɔːrfərɪn/ Mechanism of action Inhibits vitamin K epoxide reductase complex 1 (VKORC1), preventing the recycling of reduced vitamin K. This blocks the gamma-carboxylation of vitamin K--dependent clotting factors II, VII, IX, X, and proteins C and S. Anticoagulant effect is delayed; peak effect is typically delayed 72 to 96 hours (3--4 days). Warfarin is a racemic mixture; the S-enantiomer is 3--5× more potent and metabolized primarily by CYP2C9 \\[1\\]. Standard dosing -/

International Phonetic Alphabet (IPA).

Generic name: warfarin

Brand names: Coumadin, Jantoven

Therapeutic class: Vitamin K epoxide reductase antagonist (oral anticoagulant)

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