sertraline(Zoloft)
Selective serotonin reuptake inhibitor (SSRI)
Pronunciation
/ˈsɜːrtrəliːn/ Mechanism of action Selectively inhibits the presynaptic serotonin transporter (SERT), increasing serotonin availability in the synaptic cleft. Has weak effects on dopamine reuptake and minimal effect on norepinephrine. Therapeutic effect on depression and anxiety emerges over 2--6 weeks, likely via downstream receptor adaptation and neuroplasticity changes \\[1\\]. Standard dosing -/
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At a glance
- Generic name
- sertraline
- Brand names
- Zoloft
- Therapeutic class
- Selective serotonin reuptake inhibitor (SSRI)
- Mechanism (summary)
- Selectively inhibits the presynaptic serotonin transporter (SERT), increasing serotonin availability in the synaptic cleft. Has weak effects on dopamine reuptake and minimal effect on norepinephrine. Therapeutic effect on depression and anxiety emerges over 2--6 weeks, likely ...
Clinical pearls
- Take at the same time each day, with or without food (food may
- reduce nausea early on).
- It takes 4--6 weeks to feel the full effect on mood; some side
- effects (nausea, anxiety) actually peak in the first 1--2 weeks and
- then fade. Don\\'t stop just because you feel worse at first --- call
Related drugs in this class
Sources
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