omeprazole(Prilosec, Prilosec OTC, Zegerid (omeprazole + sodium bicarbonate))
Proton pump inhibitor (PPI)
Pronunciation
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At a glance
- Generic name
- omeprazole
- Brand names
- Prilosec, Prilosec OTC, Zegerid (omeprazole + sodium bicarbonate)
- Therapeutic class
- Proton pump inhibitor (PPI)
- Mechanism (summary)
- Irreversibly inhibits the H+/K+ ATPase (proton pump) in gastric parietal cells, blocking the final common step of gastric acid secretion. Prodrug activated in the acidic canaliculi of parietal cells. New proton pumps must be synthesized for acid secretion to resume; full effec...
Clinical pearls
- Take 30--60 minutes BEFORE the first meal of the day (proton pumps
- are most active after fasting). For BID dosing, the second dose is
- before dinner.
- Swallow capsules whole. If you can\\'t swallow them, open and
- sprinkle granules onto a tablespoon of applesauce; swallow
Related drugs in this class
Sources
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