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metoprolol succinate

Written by PharmD Hub Editorial TeamReviewed by PharmD Hub Editorial Team

Pronunciation

/məˈtoʊproʊlɒl ˈsʌksɪneɪt/ Mechanism of action Selectively blocks β1-adrenergic receptors in the heart, reducing heart rate, contractility, and AV nodal conduction. Lowers myocardial oxygen demand. In heart failure with reduced ejection fraction (HFrEF), chronic β1 blockade reverses sympathetic-mediated cardiac remodeling and improves survival. Selectivity diminishes at higher doses \\[1\\]. Standard dosing -/

International Phonetic Alphabet (IPA).

At a Glance

Generic name: metoprolol succinate

Brand names: Toprol-XL

Therapeutic class: Cardioselective (β1-selective) beta-blocker, extended-release

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