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levothyroxine

Pronunciation

/ˌliːvoʊθaɪˈrɒksiːn/ Mechanism of action Synthetic L-isomer of thyroxine (T4), a thyroid hormone. After absorption, T4 is converted peripherally to the more active T3 by deiodinases. T3 binds nuclear thyroid hormone receptors, modulating transcription of genes that regulate basal metabolic rate, growth, development, and cardiac, neurologic, and metabolic function. Replaces deficient endogenous thyroid hormone in hypothyroidism \\[1\\]. Standard dosing -/

International Phonetic Alphabet (IPA).

At a Glance

Generic name: levothyroxine

Brand names: Synthroid, Levoxyl, Unithroid, Tirosint (gelcap/solution), Euthyrox

Therapeutic class: Synthetic thyroid hormone (T4)

Full drug cards with dosing, warnings, interactions, and practice questions are inside NAPLEX Prep.

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