insulin glargine

/ˈɪnsəlɪn ˈɡlɑːrdʒiːn/ Mechanism of action Recombinant human insulin analog modified (asparagine → glycine at A21; two arginines added at B30) so it is soluble at acidic pH (pH 4 in vial) but precipitates at the neutral pH of subcutaneous tissue. The microprecipitate slowly dissolves, releasing insulin into circulation over \\~24 hours with a relatively flat (\\"peakless\\") profile. Binds insulin receptors, promoting glucose uptake into muscle and adipose tissue and suppressing hepatic gluconeogenesis. Provides basal insulin coverage \\[1\\]. Standard dosing -/

International Phonetic Alphabet (IPA).

Generic name: insulin glargine

Brand names: Lantus, Basaglar (biosimilar follow-on), Toujeo (concentrated U-300), Semglee (interchangeable biosimilar)

Therapeutic class: Long-acting basal insulin analog

Full drug cards with dosing, warnings, interactions, and practice questions are inside NAPLEX Prep.