insulin glargine(Lantus, Basaglar (biosimilar follow-on), Toujeo (concentrated U-300))
Long-acting basal insulin analog
Pronunciation
/ˈɪnsəlɪn ˈɡlɑːrdʒiːn/ Mechanism of action Recombinant human insulin analog modified (asparagine → glycine at A21; two arginines added at B30) so it is soluble at acidic pH (pH 4 in vial) but precipitates at the neutral pH of subcutaneous tissue. The microprecipitate slowly dissolves, releasing insulin into circulation over \\~24 hours with a relatively flat (\\"peakless\\") profile. Binds insulin receptors, promoting glucose uptake into muscle and adipose tissue and suppressing hepatic gluconeogenesis. Provides basal insulin coverage \\[1\\]. Standard dosing -/
International Phonetic Alphabet (IPA). Say it aloud once — you will remember it forever.
At a glance
- Generic name
- insulin glargine
- Brand names
- Lantus, Basaglar (biosimilar follow-on), Toujeo (concentrated U-300), Semglee (interchangeable biosimilar)
- Therapeutic class
- Long-acting basal insulin analog
- Mechanism (summary)
- Recombinant human insulin analog modified (asparagine → glycine at A21; two arginines added at B30) so it is soluble at acidic pH (pH 4 in vial) but precipitates at the neutral pH of subcutaneous tissue. The microprecipitate slowly dissolves, releasing insulin into circulation...
Clinical pearls
- This is a LONG-acting BASAL insulin. It controls blood sugar between
- meals and overnight. It does NOT cover meals --- if you also take a
- mealtime insulin, do not mix them.
- DO NOT mix glargine in the same syringe with any other insulin. Use
- a separate injection site if you take a prandial (mealtime) insulin
Sources
See how insulin glargine appears in NAPLEX-style questions
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